Microfluidic tectonics: A comprehensive construction platform for microfluidic systems

Microfluidic tectonics: a comprehensive construction platform for microfluidic systems.

A microfluidic platform for the construction of microscale components and autonomous systems is presented. The platform combines liquid-phase photopolymerization, lithography, and laminar flow to allow the creation of complex and autonomous microfluidic systems. The fabrication of channels, actuators, valves, sensors, and systems is demonstrated. Construction times can be as short as 10 min, pr...

Microfluidic Systems Integrated Microfluidic Systems**

Microfluidic systems use networks of channels thinner than a human hair to manipulate nanoliter volumes of reagents. The goal of microfluidics is challenging: to integrate, on a chip smaller than a credit card, all operations normally performed in a chemical or medical laboratory. Synthesis, purification, analysis, and diagnostics would be performed by such a “lab on a chip” rapidly, economical...

Microfluidic Systems for Biosensing

In the past two decades, Micro Fluidic Systems (MFS) have emerged as a powerful tool for biosensing, particularly in enriching and purifying molecules and cells in biological samples. Compared with conventional sensing techniques, distinctive advantages of using MFS for biomedicine include ultra-high sensitivity, higher throughput, in-situ monitoring and lower cost. This review aims to summariz...

Designs for Microfluidic Systems

Microfluidic platform for characterizing TCR-pMHC interactions.

The physical characteristics of the T cell receptor (TCR)-peptide-major histocompatibility complex (pMHC) interaction are known to play a central role in determining T cell function in the initial stages of the adaptive immune response. State-of-the-art assays can probe the kinetics of this interaction with single-molecular-bond resolution, but this precision typically comes at the cost of low ...